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篇目详细内容 |
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【篇名】 |
Electrochemical studies of reaction of ciprofloxcin and DNA |
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【刊名】 |
Frontiers of Chemistry in China |
|
【刊名缩写】 |
Front. Chem. China |
|
【ISSN】 |
1673-3495 |
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【EISSN】 |
1673-3614 |
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【DOI】 |
10.1007/s11458-008-0011-6 |
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【出版社】 |
Higher Education Press and Springer-Verlag |
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【出版年】 |
2008 |
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【卷期】 |
3
卷1期 |
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【页码】 |
52-56
页,共
5
页 |
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【作者】 |
SHI Qiaocui;
WANG Sufen;
ZHU Bin;
JI Min;
|
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【关键词】 |
ciprofloxacin; DNA; electrochemical method; interaction |
【摘要】 |
|
The electrochemical behavior of ciprofloxacin (CFX) and its interaction with the natural calf thymus DNA (ctDNA) is studied by using pulse difference voltammetry on a carbon electrode. CFX shows a well-defined oxidative peak at+ 0.88 V. As a result of reaction with ctDNA,the oxidative peak of CFX decreased markedly. According to the electrochemical equation deduced in this paper, the binding constant of 1.36 × 105 (mol/L)-1 and the binding size of 1.94 (base pairs) of CFX with ctDNA were obtained by nonlinear fit analysis of the electrochemical data. The mechanism of the interaction was explored. |
