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篇目详细内容 |
【篇名】 |
Proteome analysis of differential protein expression in infarcted rat heart after verapamil treatment |
【刊名】 |
Frontiers of Chemistry in China |
【刊名缩写】 |
Front. Chem. China |
【ISSN】 |
1673-3495 |
【EISSN】 |
1673-3614 |
【DOI】 |
10.1007/s11458-009-0020-0 |
【出版社】 |
Higher Education Press and Springer-Verlag |
【出版年】 |
2009 |
【卷期】 |
4
卷2期 |
【页码】 |
202-206
页,共
5
页 |
【作者】 |
Ying LI;
Yi WANG;
Haibin QU;
Yiyu CHENG;
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【关键词】 |
verapamil; proteomics; two-dimensional electrophoresis (2-DE); myocardial ischemia |
【摘要】 |
To explore the protein-level mechanism of action verapamil in acute myocardial infarcted rats, the myocardial proteome was analyzed by two-dimensional electrophoresis (2-DE). Compared with the sham-operated group and the infarcted group, the result shows that 8 protein expressions in the verapamil treated group were up-regulated, and 7 protein expressions in this group were down-regulated significantly. Using MALDI-TOF-MS, 15 proteins with significant changes were identified through a database search. These proteins can be divided into 4 groups by their biological function: (1) Energy metabolism and mitochondrial function related proteins; (2) oxidative stress-induced proteins; (3) cytoskeletal Proteins; (4) other proteins. The findings show that the myocardial protective effects of verapamil in the myocardial damage process are related to the recovery of energy supply as well as anti-oxidative stress property. |
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