|
篇目详细内容 |
【篇名】 |
A conjugated polymer-Gd (III) complex as pH sensitive contrast agent in magnetic resonance imaging |
【刊名】 |
Frontiers of Chemistry in China |
【刊名缩写】 |
Front. Chem. China |
【ISSN】 |
1673-3495 |
【EISSN】 |
1673-3614 |
【DOI】 |
10.1007/s11458-010-0108-6 |
【出版社】 |
Higher Education Press and Springer-Verlag Berlin
Heidelberg |
【出版年】 |
2010 |
【卷期】 |
5
卷2期 |
【页码】 |
166-170
页,共
5
页 |
【作者】 |
Qingling XU;
Libing LIU;
Litao ZHU;
Minghui YU;
Qiong YANG;
Shu WANG;
|
【关键词】 |
magnetic resonance imaging; pH-sensitive; conjugated polymer; Gd(III) chelate |
【摘要】 |
A novel pH-responsive contrast agent (PFP-aa/Gd) for magnetic resonance imaging (MRI) was prepared by binding Gd(III) to a water-soluble conjugated polyfluorene with pendant carboxylate and amine moieties. The PFP-aa is a good chelator for Gd3+ and the PFP-aa/Gd complex has good stability. As the pH changes from 10.0 to 4.0, both the carboxylate and amine are protonated, thus PFP-aa exhibits positive charges and forms tight aggregation, which reduces molecular tumbling and accelerates the exchange of bound water leading to the increase of relaxivity R1. More importantly, the R1 increases by about eight fold as the pH changes from 8.0 to 6.0, which makes PFP-aa/Gd suitable as a potential marker of the pH below physiological level. In comparison to other contrast agents, the unique sensitivity of the water relaxivity of PFP-aa/Gd indicates that this complex could be used in MRI experiments to monitor physiological pH change. |
|