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篇目详细内容 |
【篇名】 |
Dissipative particle dynamic simulation study of lipid membrane |
【刊名】 |
Frontiers of Chemistry in China |
【刊名缩写】 |
Front. Chem. China |
【ISSN】 |
1673-3495 |
【EISSN】 |
1673-3614 |
【DOI】 |
10.1007/s11458-009-0210-9 |
【出版社】 |
Higher Education Press and Springer-Verlag Berlin
Heidelberg |
【出版年】 |
2010 |
【卷期】 |
5
卷3期 |
【页码】 |
288-298
页,共
11
页 |
【作者】 |
Shaogui WU;
Teng LU;
Hongxia GUO;
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【关键词】 |
dissipative particle dynamics; lipid membrane; vesicle fusion; 2D phase transformation |
【摘要】 |
The lipid membrane plays crucial roles in countless biologic processes, ranging from cell motility, endo- and exocytosis, and cell division to protein aggregation and trafficking. To gain a molecular insight in these biologic processes, the recently developed mesoscale simulation technique, dissipative particle dynamics (DPD) simulation, has become an invaluable tool. By providing a brief survey of existing atomistic and popular coarse-grained models used today in studying the dynamics (including vesicle formation and (protein-mediated) vesicle fusion) and phase behavior of lipid bilayers, this review illustrates how mesoscopic DPD models can be used to obtain a better understanding of these biologic processes currently inaccessible to atomistic and most coarse-grained models. |
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