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篇目详细内容 |
【篇名】 |
Synthesis and biological studies of complexes of 2-amino-N(2-aminobenzoyl)benzohydrazide with Co(II), Ni(II), and Cu(II) |
【刊名】 |
Frontiers of Chemistry in China |
【刊名缩写】 |
Front. Chem. China |
【ISSN】 |
1673-3495 |
【EISSN】 |
1673-3614 |
【DOI】 |
10.1007/s11458-010-0216-3 |
【出版社】 |
Higher Education Press and Springer-Verlag Berlin
Heidelberg |
【出版年】 |
2010 |
【卷期】 |
5
卷3期 |
【页码】 |
348-356
页,共
9
页 |
【作者】 |
Saeed-Ur- Rehman;
Muhammad Ikram;
Sadia Rehman;
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【关键词】 |
2-amino-N(2-aminobezoyl)benzohydrazide; coordination compounds; bioassay studies |
【摘要】 |
The present work is concerned with the synthesis and coordination compounds of 2-amino-N(2-aminobezoyl)benzohydrazide (ABH). The ligand was synthesized by the reaction of methylanthranilate and hydrazine in 2:1 molar ratio. It can be viewed as a modified form of hydrazide. The ligand was characterized by 1H-NMR, 13C-NMR, mass spectrometry, elemental analysis, and infrared studies. The ligand has got –NH2 moeity, the site for chelation. The complexes of Co(II), Ni(II), and Cu(II) chlorides and bromides were prepared. These complexes were characterized by elemental analysis, infrared, conductance, and magnetic susceptibility studies. Infrared spectra studies confirmed the formation of complexes, while elemental studies suggested the complexation of [M(ABH)X2] (where X= Cl? or Br?) composition. Knowing about the importance of –N–N– linkage in the biologically active compounds, the synthesized complexes were studied for their biological activity, and were found to be potentially strong in inhibition activity as compared to the neat ligand. |
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