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篇目详细内容 |
【篇名】 |
Synthesis and antitumor activities of novel 2-substituted pyrimidinone-5-carboxylic acid benzylamides |
【刊名】 |
Frontiers of Chemistry in China |
【刊名缩写】 |
Front. Chem. China |
【ISSN】 |
1673-3495 |
【EISSN】 |
1673-3614 |
【DOI】 |
10.1007/s11458-007-0026-4 |
【出版社】 |
Higher Education Press and Springer-Verlag |
【出版年】 |
2007 |
【卷期】 |
2
卷2期 |
【页码】 |
127-130
页,共
4
页 |
【作者】 |
CHEN Weimin;
FENG Jin;
TU Hongyi;
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【关键词】 |
pyrimidinone; synthesis; antitumor |
【摘要】 |
The title compounds were synthesized via N-benzylmalonamic acid methyl ester (3). As the key intermediate, 3 was prepared from methyl malonyl chloride and benzylamine. Then, compound 3 was reacted with dimethylformamide dimethyl acetal yielding vinylogue amides 4 and 5. Isomers 4 and 5 were respectively treated with amidine and guanidine to afford the title compounds 2-substituted pyrimidinone-5-carboxylic acid benzylamides 6 and 7. All of the new compounds were characterized by 1H-NMR (nuclear magnetic resonance), 13C-NMR, MS and High Resolution Mass Spectrometer (HRMS). The antitumor activities of the compounds were tested in vitro against LoVo cells and Hep3B cells. Both compounds 6 and 7 show activity against these two cell lines. |
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