|
|
|
篇目详细内容 |
|
【篇名】 |
Quantitative analysis of nicotinic acid, nicotinamide and 3-cyanopyridine in industrial effluent by high performance liquid chromatography |
|
【刊名】 |
Frontiers of Chemistry in China |
|
【刊名缩写】 |
Front. Chem. China |
|
【ISSN】 |
1673-3495 |
|
【EISSN】 |
1673-3614 |
|
【DOI】 |
10.1007/s11458-007-0048-y |
|
【出版社】 |
Higher Education Press and Springer-Verlag |
|
【出版年】 |
2007 |
|
【卷期】 |
2
卷3期 |
|
【页码】 |
270-273
页,共
4
页 |
|
【作者】 |
TSANG Po Keung;
ZENG Lixuan;
|
|
【关键词】 |
heterocyclic compounds; high performance liquid chromatographic method; effluent |
【摘要】 |
|
A rapid and reliable high performance liquid chromatographic(HPLC) method for the simultaneous determination of heterocyclic compounds, namely nicotinic acid, nicotinamide, and 3-cyanopyridine, in industrial effluent is described. A Φ4.6 mm×150 mm, 5 μm C-18 reversed phase stationery phase, and a methanol-acetonitrile-water tertiary mobile phase (20:20:60 v/v) were used for separation. The detection wavelength of a diode array (DAD) was set at 216 nm with a bandwidth of 16 nm. Phenol was used as an internal standard. The regression equations revealed a linear relationship between the concentration of the analytes injected and the peak area detected by DAD. The limits of detection (S/N = 3) ranged from 0.70 to 1.18 mg L?1, the recoveries ranged from 87% to 102% and the precision expressed as % RSD intra-day and inter-day varied from 0.9 to 3.9 and 1.2 to 5.6, respectively. This method is rapid, sensitive and suitable for the monitoring of nicotinic acid, nicotinamide, and 3-cyanopyridine in effluent of related pharmaceutical manufacturing plants. |
|
