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篇目详细内容 |
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【篇名】 |
Preparation of porcine hemoglobin microcapsules of chitosan-sodium alginate |
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【刊名】 |
Frontiers of Chemistry in China |
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【刊名缩写】 |
Front. Chem. China |
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【ISSN】 |
1673-3495 |
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【EISSN】 |
1673-3614 |
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【DOI】 |
10.1007/s11458-007-0058-9 |
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【出版社】 |
Higher Education Press and Springer-Verlag |
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【出版年】 |
2007 |
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【卷期】 |
2
卷3期 |
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【页码】 |
315-317
页,共
3
页 |
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【作者】 |
LI Jun;
ZHANG Jijuan;
ZHAO Xinjuan;
YU Yan;
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【关键词】 |
chitosan-sodium alginate; microcapsules; hemo-globin; blood substitute |
【摘要】 |
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Using an emulsification-gelation method, chitosan-sodium alginate-porcine hemoglobin microcapsules were prepared. Results show that these microcapsules have better forms and small granules with 1 μm size of the mean particle size. They possess a relatively narrow and normal Gaussian distribution. The loading efficiency of porcine hemoglobin (pHb) in microcapsules is more than 90%. The pHb released from microcapsules is extended for more than one month. Chitosan-sodium alginate-hemoglobin micro capsules are expected to become an artificial oxygen-carrying therapeutic agent with sustained release for intravenous injection. |
