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篇目详细内容 |
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【篇名】 |
In vitro agonistic and antagonistic endocrine disrupting effects of organic extracts from waste water of different treatment processes |
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【刊名】 |
Frontiers of Environmental Science and Engineering in China |
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【刊名缩写】 |
Front.Environ.Sci.Engin.China |
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【ISSN】 |
2095-2201 |
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【EISSN】 |
2095-221X |
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【DOI】 |
10.1007/s11783-013-0502-7 |
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【出版社】 |
Higher Education Press and Springer-Verlag Berlin
Heidelberg |
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【出版年】 |
2014 |
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【卷期】 |
8
卷1期 |
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【页码】 |
69-78
页,共
10
页 |
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【作者】 |
Kaifeng RAO;
Na LI;
Mei MA;
Zijian WANG;
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【关键词】 |
waste water; in vitro; recombinant yeast assay; ethoxyresorufin-O-deethylase (EROD); receptor; endocrine |
【摘要】 |
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Effluents from wastewater treatment plant (WWTP) have been reported to have a broad spectrum of endocrine disrupting compounds (EDCs). The majority of studies have focused on the occurrence of estrogenic activity, while ignoring nuclear hormone receptors (NRs) pathways. In the present study, a battery of in vitro yeast bioassays and a cell bioassay, including antagonistic and agonistic effects on estrogen receptor (ER), androgen receptor (AR), progesterone receptor (PR), estrogen-related receptor (ERR) and aryl hydrocarbon receptor (AHR), were conducted to evaluate the removal efficiencies of EDCs by different treatment processes of a WWTP located in Beijing. Estrogenic, anti-estrogenic, anti- androgenic, anti-progesteronic, anti-ERR and the activation of AHR activities were detected in samples from all treatment processes and the receiving water. The concentration of estrogenic contaminants with estradiol (E2) equivalent concentrations ranged from 0.82 × 10？9 to 3.54 × 10？9？g E2-EQ·L？1. The concentration of anti-estrogenic contaminants with 4-hydroxytamoxifen (4-OHT) equivalent concentrations ranged from 1.24 × 10？6 to 2.36 × 10？6？g 4-OHT-EQ·L？1. The concentration of anti-androgenic contaminants ranged from 2.21 × 10？8 to 3.52 × 10？6？g flutamide-EQ·L？1. The concentration of anti-progesteronic contaminants ranged from 3.15 × 10？5 to 2.71 × 10？4？g RU486-EQ·L？1. The concentration of anti-ERR contaminants ranged from 7.09 × 10？5 to 6.50 × 10？4？g 4-OHT-EQ·L？1. The concentration of AHR activators ranged from 1.7 × 10？10 to 3.4 × 10？10？g TCDD-EQ·L？1. These processes including secondary clarifier, coagulation, as well as coal and sand filtration could eliminated 67.2% of estrogenic contaminants, 47.0% of anti-estrogenic contaminants, 98.3% of anti-androgenic contaminants, 88.4% of anti-progesteronic contaminants, 65.4% of anti-ERR contaminants and 46.9% of AHR activators. WWTP effluents contain multiple receptor disruptors may have very complex adverse effects on exposed organisms. |
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