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篇目详细内容

【篇名】 Optimal aspect ratio of endocytosed spherocylindrical nanoparticle
【刊名】 Frontiers of Physics
【刊名缩写】 Front. Phys.
【ISSN】 2095-0462
【EISSN】 2095-0470
【DOI】 10.1007/s11467-014-0444-y
【出版社】
【出版年】 2015
【卷期】 10 卷1期
【页码】 119-123 页,共 5 页
【作者】 Ying-Bing Chen; Yan-Hui Liu; Yan Zeng; Wei Mao; Lin Hu; Zong-Liang Mao; Hou-Qiang Xu;
【关键词】 cellular uptake|depletion effects|dimension of ligand-receptor complex|elasticity theory

【摘要】

Recent simulations have demonstrated that bioparticle size and shape modulate the process of endocytosis, and studies have provided more quantitative information that the endocytosis efficiency of spherocylindrical bioparticles is decided by its aspect ratio. At the same time, the dimensions of the receptor-ligand complex have strong effects on the size-dependent exclusion of proteins within the cellular environment. However, these earlier theoretical works including simulations did not consider the effects of ligand-receptor complex dimension on the endocytosis process. Thus, it is necessary to resolve the effects of ligand-receptor complex dimension and determine the optimal aspect ratio of spherocylindrical bioparticles in the process of endocytosis. Accordingly, we proposed a continuum elastic model, of which the results indicate that the aspect ratio depends on the ligand-receptor complex dimension and the radius of the spherocylindrical bioparticle. This model provides a phase diagram of the aspect ratio of endocytosed spherocylindrical bioparticles, the larger aspect ratio of which appears in the phase diagram with increasing ligand density, and highlights the bioparticle design.

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