(请使用IE浏览器访问本系统)

  学科分类

  基础科学

  工程技术

  生命科学

  人文社会科学

  其他

篇目详细内容

【篇名】 Metabolic control of adult neural stem cell behavior
【刊名】 Frontiers in Biology
【刊名缩写】 Front. Biol.
【ISSN】 1674-7984
【EISSN】 1674-7992
【DOI】 10.1007/s11515-015-1349-z
【出版社】
【出版年】 2015
【卷期】 10 卷2期
【页码】 100-106 页,共 7 页
【作者】 Marlen Knobloch; Sebastian Jessberger;
【关键词】 adult neurogenesis|metabolic switch|quiescence|proliferation|differentiation

【摘要】

Neural stem cells generate new neurons throughout life in distinct regions of the mammalian brain. This process, called adult neurogenesis, is important for tissue homeostasis and physiological brain function. In addition, failing or altered neurogenesis has been associated with a number of diseases such as major depression and epilepsy. Thus, understanding the molecular mechanisms governing the neurogenic process in the adult brain may enable future therapeutic approaches to target neural stem/progenitor cells (NSPCs) and their progeny to ameliorate disease symptoms and/or disease progression. Recently, the control of cellular metabolism has emerged as a regulator of NSPC activity in the adult brain. Here we review recent findings that attempt to describe stage-specific modulations of metabolism to ensure proper neurogenesis and suggest future avenues of research aiming to understand how metabolism affects NSPC behavior.

版权所有 © CALIS管理中心 2008