Chemical looping combustion is a promising technology for energy conversion due to its low-carbon, high-efficiency, and environmental-friendly feature. A vital issue for CLC process is the development of oxygen carrier, since it must have sufficient reactivity. The mechanism and kinetics of CO reduction on iron-based oxygen carriers namely pure Fe₂O₃ and Fe₂O₃ supported by alumina (Fe₂O₃/Al₂O₃) were investigated using thermo-gravimetric analysis. Fe₂O₃/Al₂O₃ showed better reactivity over bare Fe₂O₃ toward CO reduction. This was well supported by the observed higher rate constant for Fe₂O₃/Al₂O₃ over pure Fe₂O₃ with respective activation energy of 41.1±2.0 and 33.3±0.8 kJ·mol⁻¹. The proposed models were compared via statistical approach comprising Akaike information criterion with correction coupled with F-test. The phase-boundary reaction and diffusion control models approximated to 95% confidence level along with scanning electron microscopy results; revealed the promising reduction reactions of pure Fe₂O₃ and Fe₂O₃/Al₂O₃. The boosting recital of iron-based oxygen carrier support toward efficient chemical looping combustion could be explained accurately through the present study.