Extensive industrial development is a major challenge to ecological civilization construction. Industrial energy consumption and environmental pollution reduction are desperately needed. The Dongting Lake district, located in Wuhan and the Changsha-Zhuzhou-Xiangtan (CZT) pilot zone, bears the responsibility to ensure national food security and watershed ecological security, and it is an urgent need for the Dongting Lake district to accept the ecological transition of industries. On the analysis of the industrial development status and problems of the Dongting Lake district, some proposals based on the characteristics and reality of the district are pointed out, such as industrial cooperation, proper space layout, ecological innovation, industrial structure upgrading, building of ecological parks, clean production, elimination of backward production capacity, heavy metals governance and so on, as to develop the industrial ecology of the Dongting Lake district.