This paper proposes a new management mode named the persistent integration and innovation management mode to satisfy the requirements by the fast development at oilfields. Taking engineering philosophy as the guidance and technical innovations in petroleum production engineering as the breaking point, the management mode combines long term production practice at oilfields with modern management methods. The management mode integrates intellectuals, techniques, capital, and information and so on to accomplish global optimization of resource configuration. Sets of new techniques, new methods, new technologies and new equipment in petroleum production engineering have been proposed under the guidance of the management mode, achieving great social and economic benefits.