Utilizing the initial hourly monitoring data of PM_2.5 concentrations at 23 monitoring sites across the Chang-Zhu-Tan city cluster between January 2013 and February 2014 that released in Real-time Air Quality Reporting System in Hunan Province, this paper draws diagrams and analyzes the change rule of the pollutants concentration over time. In addition, this paper studies the regional distribution of PM_2.5 seasonal pollution in the vicinity of the monitoring sites using ArcGIS geographic information system with the Kriging interpolation method. On this basis, this paper puts forward some effective control strategies to cope with regional PM_2.5 pollution combined with the information of industry distribution and development status in the Chang-Zhu-Tan city cluster.