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篇目详细内容 |
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【篇名】 |
Synthesis and characterization of novel triblock copolymers comprising poly(tetrahydrofuran) as a central block and poly(γ-benzyl L-glutamate)s as outer blocks |
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【刊名】 |
Frontiers of Materials Science in China |
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【刊名缩写】 |
Front. Mater. Sci. China |
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【ISSN】 |
1673-7377 |
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【EISSN】 |
1673-7482 |
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【DOI】 |
10.1007/s11706-008-0015-7 |
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【出版社】 |
Higher Education Press and Springer-Verlag |
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【出版年】 |
2008 |
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【卷期】 |
2
卷1期 |
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【页码】 |
84-90
页,共
7
页 |
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【作者】 |
LI Hai-bin;
TIAN Zhen;
WANG Meng;
ZHANG Ai-ying;
FENG Zeng-guo;
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【关键词】 |
γ-benzyl L-glutamate N-carboxyanhydride (BLG-NCA); phenylalanine end-capped macroinitiator; poly(tetrahydrofuran) (PTHF); ring-opening polymerization (ROP); triblock polypeptide copolymer |
【摘要】 |
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BACKGROUND: Bioactive and biodegradable polyurethanes (BDPUs) have drawn much attention in recent years. As part of the research program to search for novel prepolymers for BDPUs, a study was carried out on the synthesis and characterization of triblock copolymers comprising poly(tetrahydrofuran) as a central block and poly(γ-benzyl L-glutamate)s as outer blocks. RESULTS: A new macroinitiator terminated with phenylalanine was first prepared from the condensation of a distal hydroxy poly(tetrahydrofuran) with N-tert-butoxycarbonyl L-phenylalanine in the presence of dicyclohexylcarbodiimide, followed by removing the protecting group. Then, it was employed to initiate the ring-opening polymerization of γ-benzyl L-glutamate N-carboxyanhydride in varying feeding ratios to give rise to the targeted triblock copolymers. CONCLUSIONS: The length of the outer poly(γ-benzyl L-glutamate) blocks was well tailored by varying the monomers to macroinitiator feeding ratio. All the triblock copolymers exhibited a nearly symmetrical and unimodal molecular weight distribution while only one distinct glass transition temperature was evidenced from -10°C to 25°C. |
