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篇目详细内容 |
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【篇名】 |
Expression of heat shock protein gp96 in osteosarcoma and its clinical significance |
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【刊名】 |
Frontiers of Medicine in China |
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【刊名缩写】 |
Front. Med. China |
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【ISSN】 |
1673-7342 |
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【EISSN】 |
1673-7458 |
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【DOI】 |
10.1007/s11684-008-0038-6 |
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【出版社】 |
Higher Education Press and Springer-Verlag |
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【出版年】 |
2008 |
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【卷期】 |
2
卷2期 |
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【页码】 |
200-203
页,共
4
页 |
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【作者】 |
GUO Weichun;
CHEN Anmin;
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【关键词】 |
osteosarcoma; heat shock protein gp96; immunohistochemistry |
【摘要】 |
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This study aims to detect the expression of heat shock protein gp96 (HSPgp96) in osteosarcoma and explore its role in anti-tumor immunity. Expression of HSPgp96 in 45 cases of osteosarcoma, including 24 cases of the osteoblast type, 21 cases of chondroblast type and 5 cases of normal bone tissue were detected by immunohistochemistry (IHC). The expression rate of HSPgp96 was 100% (45/45) in osteosarcoma, compared with 20% (1/5) in normal bone tissue. The average positive cell rates were 97.23% and 0.48% in osteosarcoma and normal bone tissue, respectively, and the difference between them was significant (P < 0.01). The positive cell rates in osteoblast type and chondroblast type were 97.78% and 96.56%, respectively, and the difference had no statistical significance (P > 0.05). The expression degree of HSPgp96 in osteosarcoma had a clear correlation with the pathologic degree (P < 0.05), while it had no relationship with the clinical stage (P > 0.05). The expression of HSPgp96 is high in osteosarcoma and it may be a significant index for judgment of malignancy degree and an important target site of anti-tumor immunity. |
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