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篇目详细内容 |
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【篇名】 |
Mechanism of hepatocellular damage in rat caused by low serum selenium |
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【刊名】 |
Frontiers of Medicine in China |
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【刊名缩写】 |
Front. Med. China |
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【ISSN】 |
1673-7342 |
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【EISSN】 |
1673-7458 |
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【DOI】 |
10.1007/s11684-008-0048-4 |
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【出版社】 |
Higher Education Press and Springer-Verlag |
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【出版年】 |
2008 |
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【卷期】 |
2
卷3期 |
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【页码】 |
255-258
页,共
4
页 |
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【作者】 |
LU Yi;
QU Bo;
LIU Chang;
YU Liang;
Liu Xuemin;
WANG Haohua;
JIANG An;
ZHANG Xiaogang;
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【关键词】 |
low-selenium; hepatocyte; oxidative damage; mitochondria; apoptosis |
【摘要】 |
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The aim of this paper is to investigate the mechanism of hepatocellular damage in rats caused by low serum selenium. Thirty six rats were randomly divided into 2 groups: group A (fed with low-selenium diet from the Keshan Disease area with the content of selenium being 0.017 mg/kg); group B [fed with selenium-supplemented diet and 0.3 mg/L selenium (Na2SeO3) was added to the drinking water]. Both were respectively fed for 12 weeks. At the end of the 12th week, the levels of serum selenium, glutathione peroxidase (GPX) and malondialdehyde (MDA) in hepatic tissue were measured; the hepatocellular ultrastructure and apoptosis were observed as well. The levels of serum selenium and GPX in group A were markedly lower than those in group B. MDA level in group A was significantly higher than that in group B. Under the electron microscope (EM), the mitochondria were remarkably changed in group A. The rate of liver cell apoptosis appeared much higher in group A as well. It indicated that the damage caused by selenium deficiency was through the process of oxidation. Selenium deficiency led to apoptosis of hepatocytes where oxidative damage to mitochondria might be the cause. |
