|
|
|
篇目详细内容 |
|
【篇名】 |
Serum erythropoietin and transferrin in children with idiopathic nephrotic syndrome |
|
【刊名】 |
Frontiers of Medicine in China |
|
【刊名缩写】 |
Front. Med. China |
|
【ISSN】 |
1673-7342 |
|
【EISSN】 |
1673-7458 |
|
【DOI】 |
10.1007/s11684-008-0054-6 |
|
【出版社】 |
Higher Education Press and Springer-Verlag |
|
【出版年】 |
2008 |
|
【卷期】 |
2
卷3期 |
|
【页码】 |
286-289
页,共
4
页 |
|
【作者】 |
LU Hongzhu;
WANG Lin;
FAN Qihong;
LIU Dan;
ZHANG Wanming;
YUAN Yuesha;
KUANG Hongyan;
|
|
【关键词】 |
idiopathic nephrotic syndrome; transferrin; erythropoietin; children |
【摘要】 |
|
Idiopathic nephrotic syndrome (INS) is characterized by marked urinary excretion of albumin and other intermediate-sized plasma proteins, such as transferrin and vitamin D-binding protein. Some cases even develop anemia. The aim of this study was to investigate the changes in serum iron, transferrin, and erythropoietin, and the relationships between serum and urine transferrin and erythropoietin. Thirty-seven children with INS and 35 age- and sex-matched healthy children were investigated. The indexes related to iron metabolism, including serum iron, ferritin, transferrin, total iron-binding capacity (TIBC), transferrin saturation, and hematological parameters [hemoglobin (Hb), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH)], and urinary transferrin and erythropoietin were measured in 37 children with INS before treatment and at the remission stage. Thirty-five age- and sex-matched healthy children served as controls. Serum iron levels (18.8 ± 3.8) 渭mol/L in INS patients before treatment were significantly lower than those of the healthy controls (22.2 ± 3.8) 渭mol/L and those measured at the remission stage (21.0 ± 3.5) 渭mol/L (all P < 001). Serum transferrin levels in INS patients before therapy (1.9 ± 0.3) g/L also decreased compared with the healthy controls (3.1 ± 0.5) g/L and the measures at the remission stage (2.9 ± 0.6) g/L (all P < 0.01). In contrast, serum TIBC and transferrin saturation were significantly higher in INS patients before treatment than in the healthy controls [TIBC (56.4 ± 9.2) 渭mol/L vs (50.7 ± 6.8) 渭mol/L, P < 0.01; transferrin saturation (55.7±9.2)% vs (46.4 ± 8.2)%, P < 0.01] and they were also higher than the measures at remission stage [(51.9 ± 7.7) 渭mol/L and (47.4 ± 13.3) 渭mol/L] (all P < 0.01). Serum transferrin was positively correlated with serum albumin (r = 0.609, P < 0.01) and negatively correlated with urinary transferrin (r = -0.550, P < 0.01) in INS patients before treatment. We conclude that serum iron, transferrin and erythropoietin levels are markedly decreased in INS patients, which may be partially related to the urinary loss of these indexes. |
|
