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篇目详细内容 |
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【篇名】 |
Effect of lanthanum chloride on growth of breast cancer cells and regulation of c-met transcription |
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【刊名】 |
Frontiers of Medicine in China |
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【刊名缩写】 |
Front. Med. China |
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【ISSN】 |
1673-7342 |
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【EISSN】 |
1673-7458 |
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【DOI】 |
10.1007/s11684-009-0053-2 |
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【出版社】 |
Higher Education Press and Springer-Verlag |
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【出版年】 |
2009 |
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【卷期】 |
3
卷3期 |
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【页码】 |
336-340
页,共
5
页 |
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【作者】 |
Xue LI MM;
Ping HE MM;
Jie XIA MM;
Shiwei SONG BS;
Jinhai LU BM;
Yunde LIU MM;
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【关键词】 |
proliferation; c-met; invasion; lanthanum chloride |
【摘要】 |
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Lanthanum salt is a prescription drug, but its underlying functions and mechanisms are not fully understood currently. To explore the potential therapeutic value of lanthanum chloride, cytotoxicity test was applied to investigate its effects on cell proliferation. Furthermore, we observed its influence on pro-oncogene c-met by reverse transcription polymerase chain reaction (RT-PCR). In MCF-7 cell line, lanthanum chloride repressed cell proliferation at high concentration but had no significant inhibition effect on cell growth at low concentration. However, we observed that lanthanum chloride repressed c-met transcription at a low concentration. This may suggest that lanthanum chloride is a potent drug to inhibit the high expression of c-met in carcinoma cells and play a clue for inhibiting the growth and invasion of tumor. |
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