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篇目详细内容 |
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【篇名】 |
Molecular targeted therapy of gynecological malignant tumors: the development and challenge, from laboratory to clinic |
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【刊名】 |
Frontiers of Medicine in China |
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【刊名缩写】 |
Front. Med. China |
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【ISSN】 |
1673-7342 |
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【EISSN】 |
1673-7458 |
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【DOI】 |
10.1007/s11684-009-0052-3 |
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【出版社】 |
Higher Education Press and Springer-Verlag |
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【出版年】 |
2009 |
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【卷期】 |
3
卷3期 |
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【页码】 |
256-264
页,共
9
页 |
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【作者】 |
Pengming SUN PhD, MD;
Jalid SEHOULI PhD, MD;
Lihui WEI BM;
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【关键词】 |
target therapy; gynecologic malignant tumors; clinical trail; molecular medicine |
【摘要】 |
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More and more molecular drugs based on targeted therapy have been utilized in the treatment of gynecologic cancer, especially in ovarian cancer. In this article, we systematically review the current targeted therapeutic trials running in clinic. Large, randomized trials have been conducted in the treatment of ovarian cancer, endometrial cancer and cervical cancer by using small molecule, antisense, mutational gene as well as antibodies. Other planned or ongoing trials currentlytargeted at molecular markers which may play important roles in gynecological carcinogenesis andprogression suggest that combination chemotherapy with molecular targeted therapy will ultimately be an importantoption. |
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