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篇目详细内容 |
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【篇名】 |
Expression of STAT6 and NF-κB p65 in the colon mucosa of patients with ulcerative colitis |
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【刊名】 |
Frontiers of Medicine in China |
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【刊名缩写】 |
Front. Med. China |
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【ISSN】 |
1673-7342 |
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【EISSN】 |
1673-7458 |
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【DOI】 |
10.1007/s11684-009-0086-6 |
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【出版社】 |
Higher Education Press and Springer-Verlag |
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【出版年】 |
2009 |
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【卷期】 |
3
卷4期 |
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【页码】 |
475-479
页,共
5
页 |
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【作者】 |
Rui ZHU MD;
Heng FAN MD;
Lin SHEN MD;
Jianguo LIU BD;
Jia ZHAO MM;
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【关键词】 |
ulcerative colitis; signal transducer and activator of transcription 6 (STAT6); nuclear factor-κB p65 (NF-κB p65) |
【摘要】 |
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The expression of signal transducer and activator of transcription 6 (STAT6) and nuclear factor-κB (NF-κB) in the colonic mucosa of patients with ulcerative colitis (UC) was examined. Real-time polymerase chain reaction and immunohistochemistry were used to detect the expression of STAT6 and NF-κB p65 at both mRNA and protein levels in the colonic mucosa of patients with UC and healthy volunteers. The results showed that the expression levels of STAT6 and NFκB p65 in the colonic mucosa of patients with UC were significantly higher than in normal controls at both mRNA and protein levels. These data suggest that STAT6 and NFκB p65 perhaps play an important role in the pathogenesis of UC and underscore the potential value of anti-UC strategies in the clinical management of this disease. |
