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篇目详细内容 |
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【篇名】 |
Regulation of virus-triggered type I interferon signaling by cellular and viral proteins |
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【刊名】 |
Frontiers in Biology(Formerly known as Frontiers of Biology in China) |
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【刊名缩写】 |
Front. Biol. |
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【ISSN】 |
1674-7984 |
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【EISSN】 |
1674-7992 |
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【DOI】 |
10.1007/s11515-010-0013-x |
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【出版社】 |
Higher Education Press and Springer-Verlag Berlin
Heidelberg |
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【出版年】 |
2010 |
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【卷期】 |
5
卷1期 |
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【页码】 |
12-31
页,共
20
页 |
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【作者】 |
Bo ZHONG;
Yan-Yi WANG;
Hong-Bing SHU;
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【关键词】 |
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【摘要】 |
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Host pattern recognition receptors (PRRs) recognize invading viral pathogens and initiate a series of signaling cascades that lead to the expression of type I interferons (IFNs) and inflammatory cytokines. During the past decade, significant progresses have been made to characterize PRRs such as Toll-like receptors (TLRs) and RIG-I-like receptors (RLRs) and elucidate the molecular mechanisms of TLR- and RLR-mediated signaling. To avoid excessive and harmful immune effects caused by over-activation of these signaling pathways, host cells adopt a number of strategies to regulate them. In addition, invading viruses also employ a variety of mechanisms to inhibit the production of type I IFNs, thereby evading the supervision and clearance by the host. In this review, we briefly summarize the TLR- and RLR-mediated type I IFN signaling and then focus on the mechanisms by which host cellular and viral components regulate the expression of type I IFNs. |
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