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篇目详细内容 |
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【篇名】 |
Post-transcriptional regulation of miRNA biogenesis and functions |
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【刊名】 |
Frontiers in Biology(Formerly known as Frontiers of Biology in China) |
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【刊名缩写】 |
Front. Biol. |
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【ISSN】 |
1674-7984 |
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【EISSN】 |
1674-7992 |
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【DOI】 |
10.1007/s11515-010-0004-y |
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【出版社】 |
Higher Education Press and Springer-Verlag Berlin
Heidelberg |
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【出版年】 |
2010 |
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【卷期】 |
5
卷1期 |
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【页码】 |
32-40
页,共
9
页 |
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【作者】 |
Jinbiao MA;
Ying HUANG;
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【关键词】 |
miRNA biogenesis; post-transcriptional regulation; RNA-binding proteins; hua enhancer 1 (HEN1); non-canonical poly(A) polymerase; signal transduction; post-translational modification |
【摘要】 |
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MicroRNAs (miRNAs) are a highly conserved class of small (18–24 nucleotides) non-coding RNAs that regulate a broad spectrum of biological processes. Aberrations or corruptions of miRNA functions may lead to deregulated cell proliferation, tumorigenesis, and ultimately, cancer. Increasing evidences suggested that a large fraction of miRNAs is regulated at the post-transcriptional stage, which impacts on the level and function of miRNAs during cell development and human diseases. Recently, several distinct mechanisms are emerging to regulate the biogenesis, stability and function of miRNAs at post-transcriptional level, such as specific binding to terminal loops of miRNA precursors (pri-miRNAs or pre-miRNAs) by RNA-binding proteins and 3’-terminal modifications by particular enzymes. Signaling cascades and post-translational modifications of the core components of RNA machinery also take part in the post-transcriptional regulation of miRNAs. |
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