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篇目详细内容 |
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【篇名】 |
M2 pyruvate kinase enhances HIV-1 transcription from its long terminal repeat |
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【刊名】 |
Frontiers in Biology(Formerly known as Frontiers of Biology in China) |
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【刊名缩写】 |
Front. Biol. |
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【ISSN】 |
1674-7984 |
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【EISSN】 |
1674-7992 |
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【DOI】 |
10.1007/s11515-010-0005-x |
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【出版社】 |
Higher Education Press and Springer-Verlag Berlin
Heidelberg |
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【出版年】 |
2010 |
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【卷期】 |
5
卷1期 |
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【页码】 |
59-66
页,共
8
页 |
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【作者】 |
Xiaoyun WU;
Guozhen GAO;
Musarat ISHAQ;
Tao HU;
Deyin GUO;
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【关键词】 |
Human immunodeficiency virus type 1 (HIV-1); transcription; M2 type isoenzyme of pyruvate kinase (M2PK); R type isoenzyme of pyruvate kinase (RPK); nuclear factor κB (NFκB); long terminal repeat (LTR) |
【摘要】 |
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Both thymocytes and tumor cells express M2 type isoenzyme of pyruvate kinase (M2PK), which is different from R type isoenzyme of pyruvate kinase (RPK) that is expressed in erythrocytes. In this report, the effect of RPK and M2PK on the transcription of human immunodeficiency virus type 1 (HIV-1) was tested. The results indicated that M2PK could enhance HIV-1 transcription from its long terminal repeat (LTR) promoter, while RPK did not have such an effect. Specific down-regulation of M2PK could inhibit HIV-1 transcription from its LTR region. Furthermore, it was found that the C terminal region of M2PK is responsible for this effect. Collectively, the cellular factor M2PK that is expressed in thymocytes could facilitate the transcription of HIV-1. |
