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篇目详细内容 |
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【篇名】 |
Protein microspheres for pulmonary drug delivery |
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【刊名】 |
Frontiers of Chemical Engineering in China |
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【刊名缩写】 |
Front. Chem. Eng. China |
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【ISSN】 |
1673-7369 |
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【EISSN】 |
1673-7474 |
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【DOI】 |
10.1007/s11705-009-0307-1 |
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【出版社】 |
Higher Education Press and Springer-Verlag Berlin
Heidelberg |
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【出版年】 |
2010 |
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【卷期】 |
4
卷1期 |
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【页码】 |
82-86
页,共
5
页 |
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【作者】 |
Yongda SUN;
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【关键词】 |
supercritical fluid; anti-solvent process; pulmonary drug delivery; protein microsphere; human recombinant insulin |
【摘要】 |
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A new supercritical fluid (SCF) technique was developed for the preparation of microspheres for pulmonary drug delivery (PDD). This technique, based on the anti-solvent process, has incorporated advanced engineering design features to enable improved control of the particle formation process. Human recombinant insulin (HRI) was used as a model compound to evaluate the efficiency of this SCF process. An aqueous solution of HRI with a co-solvent was sprayed into high pressure carbon dioxide that extracted the solvent and water, leading to a dry fine powder with good particle size distribution and near ideal morphology for pulmonary drug delivery. |
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