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篇目详细内容 |
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【篇名】 |
Effects of ionic impurities on crystallization of cobalamin |
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【刊名】 |
Frontiers of Chemical Engineering in China |
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【刊名缩写】 |
Front. Chem. Eng. China |
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【ISSN】 |
1673-7369 |
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【EISSN】 |
1673-7474 |
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【DOI】 |
10.1007/s11705-009-0293-3 |
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【出版社】 |
Higher Education Press and Springer-Verlag Berlin
Heidelberg |
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【出版年】 |
2010 |
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【卷期】 |
4
卷1期 |
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【页码】 |
70-74
页,共
5
页 |
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【作者】 |
Baoli SHAO;
Hui CHEN;
Shuang WANG;
Haijun WANG;
Shenmin XU;
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【关键词】 |
ionic impurities; crystallization; cobalamin; FBRM; PVM |
【摘要】 |
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In this paper, the influence of two typical ionic impurities (Na+ and Mg2+) is investigated with the focused beam reflectance measurement (FBRM) technique. In this system, the on-line FBRM is used as a tool for monitoring the crystallization process of cobalamin by measuring the chord length distribution of particles and the particle counts. It is noted that impurity Mg2+ has a more significant effect than Na2+ in crystal growth of the whole crystallization process. From the microscopic observation of crystals, Mg2+ has an obvious effect on the crystal habit, while Na2+ has little effect. In addition, the crystal habit changes can be monitored by particle vision measurement (PVM). Understanding these effects is helpful to aid optimization and improve process control. |
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