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篇目详细内容 |
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【篇名】 |
Preparation of PLGA/β-TCP composite scaffolds with supercritical CO2 foaming technique |
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【刊名】 |
Frontiers of Materials Science in China |
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【刊名缩写】 |
Front. Mater. Sci. China |
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【ISSN】 |
1673-7377 |
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【EISSN】 |
1673-7482 |
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【DOI】 |
10.1007/s11706-010-0081-5 |
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【出版社】 |
Higher Education Press and Springer-Verlag Berlin
Heidelberg |
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【出版年】 |
2010 |
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【卷期】 |
4
卷3期 |
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【页码】 |
314-320
页,共
7
页 |
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【作者】 |
Chang YANG;
Yun-Qing KANG;
Xiao-Ming LIAO;
Ya-Dong YAO;
Zhong-Bing HUANG;
Guang-Fu YIN;
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【关键词】 |
scaffold; poly(DL-lactide-co-glycolide) (PLGA); β-tricalcium phosphate (β-TCP); supercritical CO2 foaming technique |
【摘要】 |
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A high porosity scaffold with suitable compressive strength prepared by a gentle method has become a pressing need. To meet this demand, poly(DL-lactide-co-glycolide) (PLGA) and β-tricalcium phosphate (β-TCP) were designed to prepare composite scaffolds by the supercritical technique. The preparation process consisted of three units: the mixing of PLGA and β-TCP, compression molding of the mixture, and the foaming process. Six influencing factors — temperature, pressure of the scCO2 system, maintaining time of scCO2, the ratio of β-TCP to PLGA, the rate of depressurization, and the molecular weight — were investigated. The results collectively indicated that the optimized conditions for the foaming process were that CO2 pressure and temperature be 8？MPa and 39°C, respectively, which should be kept for 8？h; the content of β-TCP in the mixture should be 25% and the depressurizing rate be 0.1？MPa/s, using PLGA of an 80？kDa molecular weight. Scaffolds with a porosity of 65.47% and a compressive strength of 4.76？MPa could be obtained. The pore size ranged around 100？μm. The material’s use as tissue engineering scaffolding is expected. |
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