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篇目详细内容 |
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【篇名】 |
The effect of carboxymethyl-chitosan nanoparticles on proliferation of keloid fibroblast |
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【刊名】 |
Frontiers of Chemistry in China |
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【刊名缩写】 |
Front. Chem. China |
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【ISSN】 |
1673-3495 |
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【EISSN】 |
1673-3614 |
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【DOI】 |
10.1007/s11458-011-0229-6 |
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【出版社】 |
Higher Education Press and Springer-Verlag Berlin
Heidelberg |
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【出版年】 |
2011 |
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【卷期】 |
6
卷1期 |
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【页码】 |
31-37
页,共
7
页 |
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【作者】 |
Chao FENG;
Xiguang CHEN;
Jing ZHANG;
Gangzheng SUN;
Xiaojie CHENG;
Zhiguo WANG;
Hyun-Jin PARK;
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【关键词】 |
carboxymethyl-chitosan; nanoparticle; keloid fibroblast; proliferation |
【摘要】 |
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In this study, different molecular weight (MW) carboxymethyl chitosans (CM-chitosan) nanoparticles were prepared by ionic gelification. The particle size of nanoparticles was around 180–250？nm by dynamic light scattering (DLS) and transmission electron microscope (TEM). With the increase of CM-chitosan nanoparticles concentration from 2 to 200？μg/mL, the growth inhibition effects on the keloid fibroblast increased. At the concentration of 100？μg/mL, CM-chitosan nanoparticles with MW 6.3？kDa had a significant inhibitory effect (inhibition ratio 48.79%) of the proliferation of keloid fibroblast. Compared with CM-chitosan solution, the inhibition of CM-chitosan nanoparticles were lower in prior period and similar in later period. By analyzing the different effects of chitosan, CM-chitosan solution and CM-chitosan nanoparticles on proliferation of keloid fibroblast, we have found that the carboxylmethyl groups of CM-chitosan play an important role in inhibition of proliferation of keloid fibroblast. |
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