|
|
|
篇目详细内容 |
|
【篇名】 |
Membrane-bound O-acyltransferases (MBOAT) |
|
【刊名】 |
Frontiers in Biology |
|
【刊名缩写】 |
Front. Biol.
|
|
【ISSN】 |
1674-7984 |
|
【EISSN】 |
1674-7992 |
|
【DOI】 |
10.1007/s11515-011-1149-z |
|
【出版社】 |
Higher Education Press and Springer-Verlag Berlin
Heidelberg |
|
【出版年】 |
2011 |
|
【卷期】 |
6
卷3期 |
|
【页码】 |
177-182
页,共
6
页 |
|
【作者】 |
Catherine C. Y. CHANG;
Jie SUN;
Ta-Yuan CHANG;
|
|
【关键词】 |
cholesterol metabolism; neutral lipid biosynthesis; protein acylation; membrane phospholipid remodeling; atherosclerosis; diabetes; obesity; cancer; nutrient sensing |
【摘要】 |
|
The MBOAT enzyme family, identified in 2000, comprises 11 genes in the human genome that participate in a variety of biological processes. MBOAT enzymes contain multiple transmembrane domains and share two active site residues, histidine and asparagine. Several MBOAT members are drug targets for major human diseases, including atherosclerosis, obesity, Alzheimer disease, and viral infections. Here we review the historical aspects of MBOAT enzymes, classify them biochemically into 3 subgroups, and describe the essential features of each member. |
|
