|
篇目详细内容 |
【篇名】 |
Systems level analysis of lipidome |
【刊名】 |
Frontiers in Biology |
【刊名缩写】 |
Front. Biol.
|
【ISSN】 |
1674-7984 |
【EISSN】 |
1674-7992 |
【DOI】 |
10.1007/s11515-011-1147-1 |
【出版社】 |
Higher Education Press and Springer-Verlag Berlin
Heidelberg |
【出版年】 |
2011 |
【卷期】 |
6
卷3期 |
【页码】 |
183-189
页,共
7
页 |
【作者】 |
Guanghou SHUI;
|
【关键词】 |
lipidomics; lipid; mass spectrometry; metabolite |
【摘要】 |
Lipids, once thought to be mainly for energy-storage and structural purpose, have now gained immense recognition as a class of critical metabolites with versatile functions. The diversity and complexity of the cellular lipids are the main challenge for the comprehensive analysis of a lipidome. Lipidomics, which aims at mapping all of the lipids in a cell, is expanded rapidly in recent years, mainly attributed to recent advances in mass spectrometry (MS). MS-based lipidomic approaches developed recently allow the quick profiling of hundreds of lipids in a crude lipid extract. With the aid of latest computational tools/software (chemometrics), aberrant lipid metabolites or important signaling lipid(s) could be easily identified using unbiased lipid profiling approaches. Further tandem MS (MS/MS)-based lipidomic approaches, known as targeted approaches and able to convey structural information, hold the promise for high-throughput lipidome analysis. In this review, I discussed the basic strategy for systems level analysis of lipidome in biomedical study. |
|