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篇目详细内容 |
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【篇名】 |
ATP-dependent chromatin remodeling complex SWI/SNF in cardiogenesis and cardiac progenitor cell development |
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【刊名】 |
Frontiers in Biology |
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【刊名缩写】 |
Front. Biol.
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【ISSN】 |
1674-7984 |
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【EISSN】 |
1674-7992 |
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【DOI】 |
10.1007/s11515-012-1189-z |
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【出版社】 |
Higher Education Press and Springer-Verlag Berlin
Heidelberg |
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【出版年】 |
2012 |
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【卷期】 |
7
卷3期 |
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【页码】 |
202-211
页,共
10
页 |
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【作者】 |
Ienglam LEI;
Mai Har SHAM;
Zhong WANG;
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【关键词】 |
ATP-dependent chromatin remodeling; SWI/SNF; cardiogenesis and cardiac progenitor cell |
【摘要】 |
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The recent identification of cardiac progenitor cells (CPCs) provides a new paradigm for studying and treating heart disease. To realize the full potential of CPCs for therapeutic purposes, it is essential to understand the genetic and epigenetic mechanisms guiding CPC differentiation into cardiomyocytes, smooth muscle, or endothelial cells. ATP-dependent chromatin remodelers mediate one critical epigenetic mechanism. These large multiprotein complexes open up chromatin to modulate transcription factor access to DNA. SWI/SNF, one of the major types of chromatin remodelers, plays a key role in various aspects of development (de la Serna et al., 2006; Wu et al., 2009), including heart development and disease (Lickert et al., 2004; Wang et al., 2004; Huang et al., 2008; Stankunas et al., 2008; Hang et al., 2010). In this review, we describe the specific function of various SWI/SNF components in cardiogenesis and cardiac progenitor cell (CPC) self-renewal and differentiation. We envision that a detailed understanding of the SWI/SNF in heart development and CPC formation and differentiation will generate novel insights into epigenetic mechanisms that govern CPC differentiation and may have significant implications in understanding and treating heart disease. |
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