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篇目详细内容 |
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【篇名】 |
Synthesis of 4-hydroxymethylbenzophenone by phase transfer catalytic method |
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【刊名】 |
Frontiers of Chemistry in China |
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【刊名缩写】 |
Front. Chem. China |
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【ISSN】 |
1673-3495 |
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【EISSN】 |
1673-3614 |
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【DOI】 |
10.1007/s11458-006-0019-8 |
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【出版社】 |
Higher Education Press and Springer-Verlag |
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【出版年】 |
2006 |
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【卷期】 |
1
卷2期 |
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【页码】 |
174-178
页,共
5
页 |
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【作者】 |
Tang Ruiren;
Zhu Jinjuan;
Yan Zier;
Luo Yiming;
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【关键词】 |
phase transfer catalytic method; 4-hydroxymethylbenzophenone; mass spectrum; nuclear magnetic resonance |
【摘要】 |
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An important organic intermediate 4-hydroxymethylbenzophenone was synthesized by halogenation and hydrolyzation with phase transfer catalytic method using 4-methylbenzophenone as raw material and the technological conditions of reactions were investigated as well. Experimental results show that N-bromosuccinimide (NBS) is a good reagent to give 4-bromomethylbenzophenone undergoing a radical reaction with 4-methylbenzophenone with the yield of about 70.7%; 4-bromomethylbenzophenone can be hydrolyzed under basic conditions in the presence of phase transfer catalyst triethylbenzylammonium chloride for 5 h to give 4-hydrox-ymethylbenzophenone with yield of 84.4%. After the crude product is recrystallized from tetrahydrofuran (THF), the final product is obtained with purity above 99%. The structure of the titled compound is determined by infrared spectrum(IR), proton nuclear magnetic resonance (HNMR), and mass spectrum (MS) and elemental analysis (EA). |
