|
Three new constituents were isolated from Eleutherine americana Merr. et K. Heyne (hong-cong) by means of silica gel, octadecyl silane (ODS) column chromatography and high-performance liquid chromatography (HPLC). They were identified as (1) 9,9′-dihydroxy-8,8′-dimethoxy-1′-dimethyl-1H,1H′-[4,4′]bis[naphtha [2,3-c] funanyl]-3,3′-dione; (2) 6,8-dihydroxy-3,4-dimethoxy-1-methyl-anthraquin-one-2-carboxylic acid methyl ester; and (3) 2-acetyl-3,6,8-trihydroxy-1-methyl anthraquinone by the physico-chemical properties and spectral data, respectively. All three compounds showed weak activities against the growth of Pyricularia oryzea. The minimum morphological deformation concentration (MMDC) was 145.8, 50.2, and 124.8 μg/mL. Additionally, (2) also inhibited the proliferation of human erythroleukemia cancer cell line K562 with IC50 value of 49.1 μg/mL. |
