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篇目详细内容 |
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【篇名】 |
Mass spectrometry-based phosphoproteomics in cancer research |
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【刊名】 |
Frontiers in Biology |
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【刊名缩写】 |
Front. Biol.
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【ISSN】 |
1674-7984 |
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【EISSN】 |
1674-7992 |
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【DOI】 |
10.1007/s11515-012-2022-4 |
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【出版社】 |
Higher Education Press and Springer-Verlag Berlin
Heidelberg |
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【出版年】 |
2012 |
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【卷期】 |
7
卷6期 |
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【页码】 |
566-586
页,共
21
页 |
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【作者】 |
Xiao-Shan YUE;
Amanda B. HUMMON;
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【关键词】 |
phosphoproteomics; mass spectrometry; cancer research; phosphopeptide enrichment; quantitative phosphoproteomics; data interpretation |
【摘要】 |
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Phosphorylation is one of the most common post translational modifications (PTM), participating in a large number of processes to regulate cellular functions. Phosphorylation is also one of the key factors in the origin and development of cancer. The rapid development of mass spectrometric-based phosphoproteomic technologies has made it possible for high-throughput identification and quantification of phosphorylation events. In this review, we provide a general introduction and summary of the achievements made in mass spectrometry based phosphoproteomic research, including the approaches for phosphopeptide identification and quantification, as well as instrumentation and data interpretation methods. We also review some discoveries in cancer research made possible by phosphoproteomic analysis technologies. |
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