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篇目详细内容 |
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【篇名】 |
Susceptibility of male and female Japanese medaka (Oryzias latipes) to 2,4,6-trichlorophenol-induced micronuclei in peripheral erythrocytes |
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【刊名】 |
Frontiers of Environmental Science and Engineering in China |
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【刊名缩写】 |
Front.Environ.Sci.Engin.China |
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【ISSN】 |
2095-2201 |
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【EISSN】 |
2095-221X |
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【DOI】 |
10.1007/s11783-012-0466-z |
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【出版社】 |
Higher Education Press and Springer-Verlag Berlin
Heidelberg |
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【出版年】 |
2013 |
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【卷期】 |
7
卷1期 |
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【页码】 |
77-84
页,共
8
页 |
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【作者】 |
Nannan LIU;
Mei MA;
Yiping XU;
Jinmiao ZHA;
Kaifeng RAO;
Zijian WANG;
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【关键词】 |
2,4,6-trichlorophenol; genotoxicity; Japanese medaka; piscine micronucleus test in peripheral erythrocytes; gender difference |
【摘要】 |
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2,4,6-trichlorophenol (2,4,6-TCP) is a widespread probable human carcinogen and has been proven to have genotoxicity in in vitro assays. However, little genotoxicity information and no micronuclei induction data for 2,4,6-TCP is available from in vivo tests, especially for sex-specific differences. Following a preliminary test, a piscine peripheral erythrocyte micronucleus assay was conducted on medaka (Oryzias latipes) after a 28-day exposure to 2,4,6-TCP. In the present study, the mean micronuclei (MNC) frequencies of all of the groups increased in a dose-dependent manner, which indicated the potential genotoxicity of 2,4,6-TCP. Moreover, males were found to be more susceptible compared with females after a 28-day exposure to 2,4,6-TCP in all of the dosed groups above 10？μg·L？1. This is the first report on the potential of micronuclei induction and a sex-susceptible effect in the peripheral erythrocytes of mature fish after 2,4,6-TCP in vivo exposure. |
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