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篇目详细内容 |
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【篇名】 |
The perinucleolar compartment associates with malignancy |
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【刊名】 |
Frontiers in Biology |
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【刊名缩写】 |
Front. Biol.
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【ISSN】 |
1674-7984 |
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【EISSN】 |
1674-7992 |
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【DOI】 |
10.1007/s11515-013-1265-z |
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【出版社】 |
Higher Education Press and Springer-Verlag Berlin
Heidelberg |
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【出版年】 |
2013 |
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【卷期】 |
8
卷4期 |
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【页码】 |
369-376
页,共
8
页 |
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【作者】 |
Yiping WEN;
Chen WANG;
Sui HUANG;
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【关键词】 |
PNC; cancer; nuclear substructure; gene expression regulation; structure and function |
【摘要】 |
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The perinucleolar compartment (PNC) is a unique nuclear substructure, forming predominantly in cancer cells both in vitro and in vivo. PNC prevalence (percentage of cells containing at least one PNC) has been found to positively correlate with disease progression in several cancers (breast, ovarian, and colon). While there is a clear association between PNCs and cancer, the molecular function of the PNC remains unclear. Here we summarize the current understanding of the association of PNCs with cancer and its possible functions in cancer cells. |
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