|
|
|
篇目详细内容 |
|
【篇名】 |
MicroRNA rules: Made to be broken |
|
【刊名】 |
Frontiers in Biology |
|
【刊名缩写】 |
Front. Biol.
|
|
【ISSN】 |
1674-7984 |
|
【EISSN】 |
1674-7992 |
|
【DOI】 |
10.1007/s11515-013-1273-z |
|
【出版社】 |
Higher Education Press and Springer-Verlag Berlin
Heidelberg |
|
【出版年】 |
2013 |
|
【卷期】 |
8
卷5期 |
|
【页码】 |
468-474
页,共
7
页 |
|
【作者】 |
P.;
Shannon PENDERGRAST;
Tom VOLPE;
|
|
【关键词】 |
microRNA; post-transcriptional; gene regulation; mRNA; 3’ UTR; conservation rule; seed pairing rule; biogenesis rule; mechanism of action rule |
【摘要】 |
|
MicroRNAs (miRNAs) are important post-transcriptional regulators of gene expression. For over a decade the deluge of research describing the biogenesis and activity of miRNAs has lead researchers to postulate rules to help make sense of the enormous amount of data produced. These rules are repeated in miRNA research papers and reviews. While these rules have been helpful one must be conscious of their limitations or risk missing future breakthroughs. Here we describe some of the most commonly stated rules, the reasoning behind their formation, their uses, and limitations. |
|
