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篇目详细内容 |
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【篇名】 |
Synthesis of depsipeptides from L-amino acids and lactones |
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【刊名】 |
Frontiers of Chemical Science and Engineering |
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【刊名缩写】 |
Front. Chem. Sci. Eng |
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【ISSN】 |
2095-0179 |
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【EISSN】 |
2095-0187 |
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【DOI】 |
10.1007/s11705-011-1141-9 |
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【出版社】 |
Higher Education Press and Springer-Verlag Berlin
Heidelberg |
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【出版年】 |
2011 |
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【卷期】 |
5
卷4期 |
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【页码】 |
409-415
页,共
7
页 |
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【作者】 |
Hongfei CAO;
Yakai FENG;
Heyun WANG;
Li ZHANG;
Musammir KHAN;
Jintang GUO;
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【关键词】 |
ε-caprolactone; p-dioxanone; L-alanine; L-leucine; depsipeptide |
【摘要】 |
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By using the corresponding L-amino acid sodium as initiator, ε-caprolactone-depsipeptides CL-Ala and CL-Leu were prepared by the reactions of ε-caprolactone (CL) with L-alanine and L-leucine, respectively, and p-dioxanone-depsipeptide (PDO-Leu) was prepared by the reaction of p-dioxanone (PDO) with L-leucine. Two poly(ε-caprolactone) oligomers (PCL-Ala and PCL-Leu) of different molecular weights with depsipeptide unit were synthesized by controlling the feed ratio of L-amino acid sodium and CL. The presence of the depsipeptide structure in these obtained products was confirmed by 1H NMR spectra and the molecular weight of the poly(ε-caprolactone) oligomers was measured by gel permeation chromatography (GPC). These products contain a hydroxyl group and a carboxyl group in one molecule, which means they could act as bifunctional monomers for further polymerization to prepare high molecular weight polymers. By this way, the depsipeptide unit could be introduced into the polymers and the biodegradation rates of the novel polymers could be well controlled in vivo by the tailored molecular structures. |
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