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篇目详细内容 |
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【篇名】 |
Polymorphism and crystal transformation of penicillin sulfoxide |
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【刊名】 |
Frontiers of Chemical Science and Engineering |
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【刊名缩写】 |
Front. Chem. Sci. Eng |
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【ISSN】 |
2095-0179 |
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【EISSN】 |
2095-0187 |
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【DOI】 |
10.1007/s11705-011-1140-x |
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【出版社】 |
Higher Education Press and Springer-Verlag Berlin
Heidelberg |
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【出版年】 |
2011 |
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【卷期】 |
5
卷4期 |
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【页码】 |
442-447
页,共
6
页 |
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【作者】 |
Dingding JING;
Yongli WANG;
Zhijian CHEN;
Lina ZHOU;
Jingkang WANG;
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【关键词】 |
penicillin sulfoxide; crystallization; polymorphism; crystal transformation; Raman spectroscopy |
【摘要】 |
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Penicillin sulfoxide is the intermediate for the synthesis of 7-amino-3-desacetoxycephalosporanic acid which is one of the most important nucleuses of cephalosporin antibiotic. In this contribution, two crystal structures of penicillin sulfoxide (forms I and II) were determined by X-ray diffraction, and their thermotropic properties were investigated by differential scanning calorimetry (DSC). Furthermore, the transformation of form II to form I was studied quantitatively by Raman spectroscopy, and its rates at different temperatures were determined. The results indicate that penicillin sulfoxide is more stable as form I, and the temperature plays an important role in the crystal transformation. |
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